Conservation of binding sites for regulatory factors in the coordinately expressed α1(I) and α2(I) collagen promoters
作者： Gerard Karsenty , Benoit de Crombrugghe
DOI: 10.1016/0006-291X(91)92017-E
关键词: Transcription (biology) 、 Gene 、 Promoter 、 DNA 、 Repressor 、 Point mutation 、 Biology 、 Binding site 、 Molecular biology 、 Homology (biology)
摘要: Abstract To examine possible mechanisms for the coordinate control of α1(I) and α2(I) collagen genes, we have searched DNA binding factors that are common to both genes. We recently identified in proximal part promoter a functional site CBF, heteromeric transcriptional activator which binds certain CCAAT sequences, also sites two different repressors, designated IF1 IF2. CBF was previously shown bind activate promoter. now present evidence factor with similar characteristics as at approximately same distances from start transcription A three bp substitution mutation abolishes increases activity 4-fold propose regulation these genes is least mediated by elements.
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sci-hub.se 参考文章(8)
Jens VUUST, Mark E. SOBEL, George R. MARTIN, Regulation of type I collagen synthesis FEBS Journal. ,vol. 151, pp. 449- 453 ,(1985) , 10.1111/J.1432-1033.1985.TB09122.X
G Karsenty, B de Crombrugghe, Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene. Journal of Biological Chemistry. ,vol. 265, pp. 9934- 9942 ,(1990) , 10.1016/S0021-9258(19)38761-7
G Karsenty, P Golumbek, B de Crombrugghe, Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter. Journal of Biological Chemistry. ,vol. 263, pp. 13909- 13915 ,(1988) , 10.1016/S0021-9258(18)68330-9
W J de Wet, M L Chu, D J Prockop, The mRNAs for the pro-alpha 1(I) and pro-alpha 2(I) chains of type I procollagen are translated at the same rate in normal human fibroblasts and in fibroblasts from two variants of osteogenesis imperfecta with altered steady state ratios of the two mRNAs. Journal of Biological Chemistry. ,vol. 258, pp. 14385- 14389 ,(1983) , 10.1016/S0021-9258(17)43873-7
A Hatamochi, P T Golumbek, E Van Schaftingen, B de Crombrugghe, A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding. Journal of Biological Chemistry. ,vol. 263, pp. 5940- 5947 ,(1988) , 10.1016/S0021-9258(18)60657-X
C Chen, H Okayama, High-efficiency transformation of mammalian cells by plasmid DNA. Molecular and Cellular Biology. ,vol. 7, pp. 2745- 2752 ,(1987) , 10.1128/MCB.7.8.2745
S. Maity, P. Golumbek, G Karsenty, B de Crombrugghe, Selective activation of transcription by a novel CCAAT binding factor Science. ,vol. 241, pp. 582- 585 ,(1988) , 10.1126/SCIENCE.3399893
C M Gorman, L F Moffat, B H Howard, Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Molecular and Cellular Biology. ,vol. 2, pp. 1044- 1051 ,(1982) , 10.1128/MCB.2.9.1044