Cationic porphyrins and analogues as new DNA topoisomerase I and II inhibitors.
作者： Li Shuai , Shaoru Wang , Lixia Zhang , Boqiao Fu , Xiang Zhou
关键词: Plasma protein binding 、 Stereochemistry 、 Topoisomerase-II Inhibitor 、 Topoisomerase-I Inhibitor 、 Cationic polymerization 、 Chemistry 、 In vitro 、 Topoisomerase 、 Covalent bond 、 DNA
摘要: A series of cationic porphyrins, and analogues such as corroles phthalocyanines were found to have biological activities towards topoisomerases I II in vitro. Cationic porphyrins do not induce Topo I-DNA covalent complexes but inhibit topoisomerase by direct binding DNA, which limits access the DNA substrate. The lowest concentration where an inhibition effect is clearly visible some derivatives between 0.1 0.6 microM. Furthermore, activity II.
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