Combined intraoperative radiation and perioperative chemotherapy for unresectable cancers of the pancreas.
作者： M Mohiuddin , W F Regine , J Stevens , F Rosato , D Barbot
DOI: 10.1200/JCO.1995.13.11.2764
关键词: Surgery 、 Intraoperative radiation therapy 、 Fluorouracil 、 Radiation therapy 、 Chemotherapy 、 Pancreas 、 Medicine 、 Adenocarcinoma 、 Pancreatic disease 、 Perioperative
摘要: PURPOSETo evaluate the effectiveness of combined intraoperative radiation therapy (IORT) and perioperative chemotherapy in management unresectable pancreatic cancer.MATERIALS AND METHODSForty-nine patients with localized adenocarcinoma pancreas were treated a multimodality program initial IORT (fluorouracil [5-FU]/leucovorin) followed by external-beam (40 to 55 Gy) continued chemotherapy. Patients evaluated for toxicity, pattern failure, survival. The follow-up times these range from minimum 12 months maximum 62 months, median 28 months.RESULTSThe incidence mortality was 0%. Early postsurgical morbidity (grade 3/4) observed seven 49 (14%) late treatment-related eight 43 (19%) alive beyond 6 months. Morbidity primarily gastrointestinal (GI), no hematologic toxicities observed. su...
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