Serum levels of insulin-like growth factor-1 and brain-derived neurotrophic factor as potential recovery biomarkers in stroke.

摘要: OBJECTIVES Our objectives were: 1) to determine whether maximal aerobic exercise increased serum neurotrophins in chronic stroke and 2) the factors that predict resting exercise-dependent levels. METHODS We investigated potential predictors of insulin-like growth factor-1 brain-derived neurotrophic factor among 35 patients. Predictors from three domains (demographic, disease burden, cardiometabolic) were entered into 4 separate stepwise linear regression models with outcome variables: factor, change factor. RESULTS Insulin-like decreased after (p = 0.001) while did not (p = 0.38). Greater lower extremity impairment predicted higher (p = 0.004, r2 = 0.23). Higher fluid intelligence greater response (p = 0.01, r2 = 0.18). There no significant or percent factor-1. DISCUSSION Biomarkers have characterize an individual's for recovery stroke. Neurotrophins such as are thought be important neurorehabilitation; however, modulate these biomarkers well understood. Resting related physical cognitive stroke, albeit weakly. was informative biomarker The novel finding positively correlated exercise-induced warrants further research.