Brain-Derived Neurotrophic Factor Contributes to Recovery of Skilled Reaching After Focal Ischemia in Rats
作者： Michelle Ploughman , Victoria Windle , Crystal L. MacLellan , Nicole White , Jules J. Doré
DOI: 10.1161/STROKEAHA.108.531806
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摘要: Background and Purpose— Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival, synaptic plasticity, learning memory, neuroplasticity. Further, exogenous treatment with BDNF or exposing animals to enrichment exercise regimens, which also increase BDNF, enhances behavioral recovery after brain injury. Thus, the beneficial effects of rehabilitation promoting stroke may depend on BDNF. We tested this hypothesis by evaluating contribution motor skill relearning endothelin-1–induced middle cerebral artery occlusion rats. Methods— Antisense oligonucleotide, blocks expression (or saline vehicle) was infused into contralateral lateral ventricle for 28 days ischemia. Animals received either a graduated program, including running skilled reaching training, simulates clinical practice, no rehabilitation. Functional assessed battery tests that measu...
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