Bridging cell wall biosynthesis and bacterial morphogenesis.

作者: Pierre-Jean Matteï , David Neves , Andréa Dessen

DOI: 10.1016/J.SBI.2010.09.014

关键词: Bacterial cell structureCytoplasmProkaryotic cytoskeletonMreBMorphogenesisPeriplasmic spacePeptidoglycanCell wallBiologyCell biology

摘要: The bacterial cell wall is a complex three-dimensional structure that protects the from environmental stress and ensures its shape. biosynthesis of main component, peptidoglycan, involves coordination activities proteins present in cytoplasm, membrane, periplasm, some which also interact with cytoskeleton. sheer complexity elongation process, focus this review, has created significant challenge for study macromolecular interactions regulate peptidoglycan biosynthesis. availability new structural biochemical data on number components assembly machineries, including between MreB RodZ as well structures penicillin-binding (PBPs) pathogenic species, now provide novel insight into underpinnings an intricate molecular machinery.

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