Chapter Sixteen – Advances in Inhibitors of Penicillin-Binding Proteins and β-Lactamases as Antibacterial Agents

摘要: Abstract The continued rise of multidrug-resistant bacterial infections poses a significant threat to public health and has prompted the pharmaceutical industry reinvest in discovery new antibiotics with increased potency expanded spectrum against these lethal pathogens. Although many excellent antibacterial targets exist, penicillin-binding proteins remain most clinically successful well-understood currently by researchers. classic β-lactam motif continues be primary driver this field N th generation β-lactams as major focus research. In addition, evolution β-lactamase (BL) resistance-particularly Gram-negative pathogens-has pushed develop both non-β-lactam inhibitors PBPs well direct BL enzymes themselves, dosed concurrently antibiotic. This review will summarize recent advances development PBP serine metallo-β-lactamase for treatment infections.