Flexible inorganic composite nanofibers with carboxyl modification for controllable drug delivery and enhanced optical monitoring functionality

摘要: Abstract Nanofibers with controllable drug release and sensitive monitoring properties for delivery can regulate the rate obtain real-time information between amount therapeutic effect, which are of great importance in clinical applications. Herein, we introduce a reoxidation method to prepare flexibility-enhanced inorganic nanofibers that does not need traditional high temperature calcination. Compared calcination methods, stronger upconversion luminescence is obtained via this method. More interestingly, higher loading capacity slower releasing after modified carboxyl. The main mechanism ascribed ionic interaction DNR molecules carboxyl group verified by FTIR. Further experimental results show be achieved only modification, but also change pH. Moreover, thanks prepared possessing luminescence, they exhibit more especially trace such as 1% cannot well monitored methods.