Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma
作者： Stephen K. Chia , Charles C. Wykoff , Peter H. Watson , Cheng Han , Russell D. Leek
DOI: 10.1200/JCO.2001.19.16.3660
关键词: Mammary gland 、 Pathology 、 Breast cancer 、 Carbonic Anhydrase 9 、 Oncology 、 CA 15-3 、 Carcinoma 、 Monoclonal 、 Survival analysis 、 Medicine 、 Immunohistochemistry 、 Internal medicine
摘要: PURPOSE: To assess the frequency of expression and prognostic significance a hypoxia-regulated marker, carbonic anhydrase IX (CA IX), in cohort patients with invasive breast cancer. PATIENTS AND METHODS: CA was evaluated by immunohistochemistry murine monoclonal antibody, M75, series 103 women treated surgically for The majority were adjuvant hormonal or chemotherapy. expression, its association recognized factors, relationship outcome univariate multivariate statistical analyses. RESULTS: present 49 (48%) cases. level found to be significantly associated tumor necrosis (P < .001), higher grade = .02), negative estrogen receptor status .001). Furthermore, relapse rate .004) worse overall survival By mul...
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