Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1

作者: Robert M. Vaughan , Bradley M. Dickson , Matthew F. Whelihan , Andrea L. Johnstone , Evan M. Cornett

DOI: 10.1073/PNAS.1806373115

关键词: Ubiquitin ligaseCell biologyChemistryDNA methylationHistone H3HistoneNucleosomeChromatinLinker DNAEpigenetics

摘要: … H3 ubiquitination occurs in the wake of replicating DNA polymerase at H3K9me2/me3-marked nucleosomes adjacent to regions of HeDNA (Fig. 4B). This serves as a nucleation event …

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