The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation.
作者： Scott B. Rothbart , Bradley M. Dickson , Robert M. Vaughan
关键词: DNA-binding protein 、 Ubiquitin ligase 、 DNA methylation 、 DNA 、 Cell biology 、 Chemistry 、 Ring finger 、 Histone 、 Ubiquitin 、 DNA methyltransferase
摘要: … UHRF1 oncogenic activity in colon cancer cells, highlighting that UHRF1 SRA antagonism … as a regulator of UHRF1 ubiquitin targeting and DNA methylation maintenance. A chimeric …
sci-hub.se 参考文章(38)
Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl, GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation Journal of Chemical Theory and Computation. ,vol. 4, pp. 435- 447 ,(2008) , 10.1021/CT700301Q
Eerappa Rajakumara*, Julie A Law*, Dhirendra K Simanshu, Philipp Voigt, Lianna M Johnson, Danny Reinberg, Dinshaw J Patel, Steven E Jacobsen, (* Equal contribution), A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo Genes & Development. ,vol. 25, pp. 137- 152 ,(2011) , 10.1101/GAD.1980311
Ting Zhou, Jun Xiong, Mingzhu Wang, Na Yang, Jiemin Wong, Bing Zhu, Rui-Ming Xu, Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2 Molecular Cell. ,vol. 54, pp. 879- 886 ,(2014) , 10.1016/J.MOLCEL.2014.04.003
George V. Avvakumov, John R. Walker, Sheng Xue, Yanjun Li, Shili Duan, Christian Bronner, Cheryl H. Arrowsmith, Sirano Dhe-Paganon, Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 Nature. ,vol. 455, pp. 822- 825 ,(2008) , 10.1038/NATURE07273
Hideharu Hashimoto, John R. Horton, Xing Zhang, Magnolia Bostick, Steven E. Jacobsen, Xiaodong Cheng, The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix Nature. ,vol. 455, pp. 826- 829 ,(2008) , 10.1038/NATURE07280
Liang Zhang, Xingyu Lu, Junyan Lu, Haihua Liang, Qing Dai, Guo-Liang Xu, Cheng Luo, Hualiang Jiang, Chuan He, Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA Nature Chemical Biology. ,vol. 8, pp. 328- 330 ,(2012) , 10.1038/NCHEMBIO.914
Caterina Bianchi, Ronen Zangi, Dual base-flipping of cytosines in a CpG dinucleotide sequence Biophysical Chemistry. ,vol. 187, pp. 14- 22 ,(2014) , 10.1016/J.BPC.2013.12.005
Niu Huang, Alexander D. MacKerell, Atomistic view of base flipping in DNA. Philosophical Transactions of the Royal Society A. ,vol. 362, pp. 1439- 1460 ,(2004) , 10.1098/RSTA.2004.1383
Rasa Sukackaite, Saulius Grazulis, Gintautas Tamulaitis, Virginijus Siksnys, The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine. Nucleic Acids Research. ,vol. 40, pp. 7552- 7562 ,(2012) , 10.1093/NAR/GKS332
Jiamu Du, Lianna M. Johnson, Martin Groth, Suhua Feng, Christopher J. Hale, Sisi Li, Ajay A. Vashisht, Javier Gallego-Bartolome, James A. Wohlschlegel, Dinshaw J. Patel, Steven E. Jacobsen, Mechanism of DNA methylation-directed histone methylation by KRYPTONITE Molecular Cell. ,vol. 55, pp. 495- 504 ,(2014) , 10.1016/J.MOLCEL.2014.06.009