Plasma-assisted heparin conjugation on electrospun poly(L-lactide) fibrous scaffolds.
作者： Q. Cheng , K. Komvopoulos , S. Li
DOI: 10.1002/JBM.A.34802
关键词: Electrospinning 、 Surface modification 、 Heparin 、 Derivatization 、 Hydrolysis 、 Polyester 、 Amine gas treating 、 Materials science 、 Covalent bond 、 Polymer chemistry
摘要: Heparin conjugation on poly(l-lactide) fibrous scaffolds fabricated by electrospinning was accomplished surface functionalization with amine (–NH2) groups using a sequential treatment Ar-NH3 and H2 plasmas. The density of the incorporated –NH2 determined combining chemical derivatization method X-ray photoelectron spectroscopy. time plasma significantly affected N/C, –NH2/N, –NH2/C fractions, whereas power, gas composition, only influenced –NH2/N fractions. Scaffold increased amount covalently bonded heparin compared to hydrolysis method. function immobilized confirmed decrease platelet attachment during exposure blood from Sprague-Dawley rats. In vitro experiments bovine aorta endothelial cells demonstrated that enhanced cell infiltration through scaffolds, regardless heparin. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1408–1414, 2014.
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