The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease

摘要: Poor vascular homeostasis drives many clinical disorders including diabetes, arthritis, atherosclerosis, and peripheral artery disease. Local tissue ischemia resultant of insufficient blood flow is a potent stimulus for recruitment endothelial progenitor cells (EPCs). This mobilization homing multi-step process involving EPC detachment from their steady state bone marrow niches, entry into circulation, rolling along vessel endothelium, transmigration, adhesion to denuded extracellular matrix (ECM) where they may participate in neovessel formation. However, these events are often interrupted pathological conditions partly due an imbalance factor presentation at the level. number function impaired patients with diseases this dysfunction has been proposed as prominent contributor disease pathogenesis. Research approaches aimed providing therapeutic angiogenesis commonly involve delivery proangiogenic and/or soluble factors. Nevertheless, greater understanding mechanisms involved both healthy diseased states critical improving efficacy such strategies. review underscores matrix-related signals necessary enhancing ischemic provides overview development synthetic ECMs that aim mimic functions local native microenvironment use angiogenesis.