Cell–cell communication and axis specification in the Drosophila oocyte

摘要: Intercellular communication between the somatic and germline cells is vital to development of Drosophila egg chamber. One critical outcome this polarization oocyte along anterior-posterior axis, a process induced by an unknown signal from follicle oocyte. The existence has been inferred several reports demonstrating that differentiation patterning spatially restricted activation certain cell-signaling pathways necessary for axis formation in These have also provided framework understanding how these signaling are integrated generate follicle-cell pattern, but precise role remains enigmatic. Research identified genes appear be involved polarizing Interestingly proteins encoded most associated with extracellular matrix, suggesting pivotal complex biological component This review summarizes findings area, uses experimental analyses evaluate various models describing possible nature signal, it.