Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts.
作者： Aaron Voigt , Ralf Pflanz , Ulrich Schäfer , Herbert Jäckle
DOI: 10.1002/DVDY.10120
关键词:
摘要: Drosophila neuroblasts act as stem cells. Their proliferation is controlled through cell cycle arrest and activation in a spatiotemporal pattern. Several genes have been identified that control the pattern of neuroblast quiescence central nervous system (CNS), including anachronism (ana), even skipped (eve) terribly reduced optic lobes (trol). eve acts non-cell-autonomous manner to produce transacting factor larval body stimulates division population quiescent lobe neuroblasts. ana encodes secreted glial glycoprotein proposed repress premature thoracic trol was shown downstream activate either by inactivating or bypassing ana-dependent repression. Here, we show codes for Perlecan, large multidomain heparan sulfate proteoglycan originally extracellular matrix structures mammals. The results suggest binds, stores, sequesters external signals and, thereby, participates stage- region-specific proliferation.
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