Lung cancer screening: a different paradigm.
作者： Annette McWilliams , John Mayo , Sharyn MacDonald , Jean C. leRiche , Branko Palcic
DOI: 10.1164/RCCM.200301-144OC
关键词: Intensive care 、 Cancer 、 Lung cancer screening 、 Lung cancer 、 Atypia 、 Medicine 、 Radiology 、 Respiratory disease 、 Sputum 、 Carcinoma in situ
摘要: Thoracic computed tomography (CT) is a sensitive method for detecting early lung cancer but has high false-positive rate and not central preinvasive microinvasive cancer. Our hypothesis was that automated quantitative image cytometry (AQC) of sputum cells as the first screening may improve detection by identifying individuals at highest risk A total 561 volunteer current or former smokers 50 years age older, with smoking history more than equal to 30 pack/years, were studied. Among these, 423 found have atypia defined five abnormal DNA content using AQC. Noncalcified pulmonary nodules in 46% (259/561). Of 14 detected cancers, 13 subjects atypia-nine CT four carcinoma situ/microinvasive cancers autofluorescence bronchoscopy. One alone. AQC improved from 1.8 3.1%. scan alone would missed 29% cancers. This paradigm shift additional potential reducing number initial scans least 25% further savings follow-up investigations treatment.
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