In silico analysis of Single Nucleotide Polymorphisms (SNPs) in human BRAF gene

作者: Muhammad Ramzan Manwar Hussain , Noor Ahmad Shaik , Jumana Yousuf Al-Aama , Hani Z. Asfour , Fatima Subhani Khan

DOI: 10.1016/J.GENE.2012.07.014

关键词: In silicodbSNPSingle-nucleotide polymorphismGeneBiologyGenomicsV600EProtein structureGeneticsGene mutation

摘要: … Therefore, an effort was made to identify SNPs that can modify the structure, function and expression of the BRAF gene. As described in the methodology section, a computational …

参考文章(33)
R. Rajasekaran, C. Sudandiradoss, C. George Priya Doss, Rao Sethumadhavan, Identification and in silico analysis of functional SNPs of the BRCA1 gene. Genomics. ,vol. 90, pp. 447- 452 ,(2007) , 10.1016/J.YGENO.2007.07.004
Remo Calabrese, Emidio Capriotti, Piero Fariselli, Pier Luigi Martelli, Rita Casadio, Functional annotations improve the predictive score of human disease-related mutations in proteins Human Mutation. ,vol. 30, pp. 1237- 1244 ,(2009) , 10.1002/HUMU.21047
Anna Sarkozy, Claudio Carta, Sonia Moretti, Giuseppe Zampino, Maria C Digilio, Francesca Pantaleoni, Anna Paola Scioletti, Giorgia Esposito, Viviana Cordeddu, Francesca Lepri, Valentina Petrangeli, Maria L Dentici, Grazia MS Mancini, Angelo Selicorni, Cesare Rossi, Laura Mazzanti, Bruno Marino, Giovanni B Ferrero, Margherita Cirillo Silengo, Luigi Memo, Franco Stanzial, Francesca Faravelli, Liborio Stuppia, Efisio Puxeddu, Bruce D Gelb, Bruno Dallapiccola, Marco Tartaglia, None, Germline BRAF mutations in noonan, LEOPARD, and cardiofaciocutaneous Syndromes: Molecular diversity and associated phenotypic spectrum Human Mutation. ,vol. 30, pp. 695- 702 ,(2009) , 10.1002/HUMU.20955
A. Jemal, S. S. Devesa, P. Hartge, M. A. Tucker, Recent Trends in Cutaneous Melanoma Incidence Among Whites in the United States Journal of the National Cancer Institute. ,vol. 93, pp. 678- 683 ,(2001) , 10.1093/JNCI/93.9.678
Sitao Wu, Yang Zhang, MUSTER: Improving protein sequence profile-profile alignments by using multiple sources of structure information Proteins: Structure, Function, and Bioinformatics. ,vol. 72, pp. 547- 556 ,(2008) , 10.1002/PROT.21945
D Fredman, Marianne Siegfried, Yan P Yuan, Peer Bork, Heikki Lehväslaiho, Anthony J Brookes, HGVbase: a human sequence variation database emphasizing data quality and a broad spectrum of data sources Nucleic Acids Research. ,vol. 30, pp. 387- 391 ,(2002) , 10.1093/NAR/30.1.387
Harith Rajagopalan, Alberto Bardelli, Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Victor E. Velculescu, Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature. ,vol. 418, pp. 934- 934 ,(2002) , 10.1038/418934A
Bent Petersen, Thomas Petersen, Pernille Andersen, Morten Nielsen, Claus Lundegaard, A generic method for assignment of reliability scores applied to solvent accessibility predictions BMC Structural Biology. ,vol. 9, pp. 51- 51 ,(2009) , 10.1186/1472-6807-9-51
Masao Omata, Tsuneo Ikenoue, Yohko Hikiba, Fumihiko Kanai, Hideaki Ijichi, Goichi Togo, Miki Ohta, Hirotsugu Watabe, Yutaka Yamaji, Makoto Okamoto, Jun Aragaki, Masayuki Matsumura, Takao Kawabe, Rapid detection of mutations in the BRAF gene using real-time polymerase chain reaction and melting curve analysis Cancer Genetics and Cytogenetics. ,vol. 149, pp. 68- 71 ,(2004) , 10.1016/S0165-4608(03)00299-1
J. Schymkowitz, J. Borg, F. Stricher, R. Nys, F. Rousseau, L. Serrano, The FoldX web server: an online force field Nucleic Acids Research. ,vol. 33, pp. 382- 388 ,(2005) , 10.1093/NAR/GKI387