Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts
作者： Yanmei Chen , Zhongwei Du , Zhen Yao , None
关键词: Anatomy 、 Homeobox 、 Embryonic stem cell 、 Endoderm 、 Homeobox protein NANOG 、 Biology 、 Cell biology 、 Embryonal carcinoma 、 Cell culture 、 Transcription factor 、 Rex1 、 Molecular biology
摘要: Nanog is a recently discovered homeodomain transcription factor that sustains the pluripotency of embryonic stem (ES) cells and blocks their differentiation into endoderm. The murine F9 embryonal carcinoma cell line well-documented model system for endoderm lineage differentiation. Here, we examined function in Over-expression returns to early status ES represses primitive parietal cells, whereas it has no effect on visceral In contrast, expression C-terminal domain-truncated spontaneously promotes cells. These data suggest required sustain proper undifferentiated domain transduces most effects repressing
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