A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

作者: Xin Zhang , Irina Neganova , Stefan Przyborski , Chunbo Yang , Michael Cooke

DOI: 10.1083/JCB.200801009

关键词:

摘要: … To investigate how NANOG regulates S-phase entry in hESCs, we first performed direct immunoblotting for the expression of key cell cycle components involved in the G1 to S transition …

参考文章(30)
Paromita Deb-Rinker, Dao Ly, Anna Jezierski, Marianna Sikorska, P. Roy Walker, Sequential DNA Methylation of the Nanog and Oct-4 Upstream Regions in Human NT2 Cells during Neuronal Differentiation Journal of Biological Chemistry. ,vol. 280, pp. 6257- 6260 ,(2005) , 10.1074/JBC.C400479200
Niels Mailand, Alexandre V Podtelejnikov, Anja Groth, Matthias Mann, Jiri Bartek, Jiri Lukas, None, Regulation of G2/M events by Cdc25A through phosphorylation-dependent modulation of its stability The EMBO Journal. ,vol. 21, pp. 5911- 5920 ,(2002) , 10.1093/EMBOJ/CDF567
Tongxiang Lin, Connie Chao, Shin'ichi Saito, Sharlyn J. Mazur, Maureen E. Murphy, Ettore Appella, Yang Xu, p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression Nature Cell Biology. ,vol. 7, pp. 165- 171 ,(2005) , 10.1038/NCB1211
Thomas Pratt, Linda Sharp, Jenny Nichols, David J. Price, John O. Mason, Embryonic stem cells and transgenic mice ubiquitously expressing a tau-tagged green fluorescent protein. Developmental Biology. ,vol. 228, pp. 19- 28 ,(2000) , 10.1006/DBIO.2000.9935
Yanmei Chen, Zhongwei Du, Zhen Yao, None, Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts Cell Research. ,vol. 16, pp. 641- 650 ,(2006) , 10.1038/SJ.CR.7310067
Jianlong Wang, Sridhar Rao, Jianlin Chu, Xiaohua Shen, Dana N. Levasseur, Thorold W. Theunissen, Stuart H. Orkin, A protein interaction network for pluripotency of embryonic stem cells Nature. ,vol. 444, pp. 364- 368 ,(2006) , 10.1038/NATURE05284
Steven J. Greco, Katherine Liu, Pranela Rameshwar, Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. Stem Cells. ,vol. 25, pp. 3143- 3154 ,(2007) , 10.1634/STEMCELLS.2007-0351
Louise Hyslop, Miodrag Stojkovic, Lyle Armstrong, Theresia Walter, Petra Stojkovic, Stefan Przyborski, Mary Herbert, Alison Murdoch, Tom Strachan, Majlinda Lako, Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. Stem Cells. ,vol. 23, pp. 1035- 1043 ,(2005) , 10.1634/STEMCELLS.2005-0080
Klaus A. Becker, Prachi N. Ghule, Jaclyn A. Therrien, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, Gary S. Stein, Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase Journal of Cellular Physiology. ,vol. 209, pp. 883- 893 ,(2006) , 10.1002/JCP.20776
Amar M. Singh, Takashi Hamazaki, Katherine E. Hankowski, Naohiro Terada, A Heterogeneous Expression Pattern for Nanog in Embryonic Stem Cells Stem Cells. ,vol. 25, pp. 2534- 2542 ,(2007) , 10.1634/STEMCELLS.2007-0126