Molecular Species of Phosphatidylinositol-Cycle Intermediates in the Endoplasmic Reticulum and Plasma Membrane
作者： Yulia V. Shulga , David S. Myers , Pavlina T. Ivanova , Stephen B. Milne , H. Alex Brown
DOI: 10.1021/BI901551E
关键词: Membrane 、 Phosphatidic acid 、 Endoplasmic reticulum 、 Chemistry 、 Pi 、 Diacylglycerol kinase 、 Cell membrane 、 Biochemistry 、 Cell fractionation 、 Phosphatidylinositol
摘要: Phosphatidylinositol (PI) turnover is a process requiring both the plasma and ER membranes. We have determined distribution of phosphatidic acid (PA) PI their acyl chain compositions in these two subcellular membranes using mass spectrometry. assessed role cycling determining molecular species quantity lipids by comparing isolated from embryonic fibroblasts obtained diacylglycerol kinase e (DGKe) knockout (KO) wild-type (WT) mice. In KO cells, conversion arachidonoyl-rich DAG to PA blocked absence DGKe, resulting reduction rate cycling. The composition very similar for endoplasmic reticulum (ER) versus membrane (PM) WT KO. However, profile different that PA. This indicates DGKe not facilitating direct transfer specific between PM ER. Approxi...
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