Cadmium modification of cell growth and specific gene expression in normal rat-kidney fibroblast cells
作者： Ning Tang
DOI: 10.31274/RTD-180813-12890
关键词: Cadmium 、 Cell growth 、 Fibroblast 、 Amino acid 、 Genetics 、 Molecular biology 、 Messenger RNA 、 Protein biosynthesis 、 Gene expression 、 DNA synthesis 、 Biology
摘要: Cadmium (Cd++, hereafter) inhibits EGF-induced ^H-Tdr incorporation in serum starved NRK-49F cells a dose dependent pattern. The underlying mechanisms for this inhibition are largely unknown. mvc mRNA accumulation and the effects of Cd++on response were examined under conditions that result partial or complete DNA synthesis. It was found doses Cd++ inhibit synthesis do not protein accumulation. 0.5 uM 1 actually to increase amino acid incorporation. These results show effect on is due entrance into Gl, but rather acts events subsequent accumulation; is, associated with either G1 progression, entry S
sci-hub.st 参考文章(51)
M. D. Enger, C. E. Hildebrand, J. Seagrave, R. A. Tobey, Cellular Resistance to Cadmium Handbook of Experimental Pharmacology. pp. 363- 396 ,(1986) , 10.1007/978-3-642-70856-5_11
J B Smith, S D Dwyer, L Smith, Cadmium evokes inositol polyphosphate formation and calcium mobilization. Evidence for a cell surface receptor that cadmium stimulates and zinc antagonizes. Journal of Biological Chemistry. ,vol. 264, pp. 7115- 7118 ,(1989) , 10.1016/S0021-9258(18)83208-2
P. Jin, N.R. Ringertz, Cadmium induces transcription of proto-oncogenes c-jun and c-myc in rat L6 myoblasts. Journal of Biological Chemistry. ,vol. 265, pp. 14061- 14064 ,(1990) , 10.1016/S0021-9258(18)77266-9
Cheryl Walker, Paul Nettesheim, In Vitro Transformation of Primary Rat Tracheal Epithelial Cells by 5-Azacytidine Cancer Research. ,vol. 46, pp. 6433- 6437 ,(1986)
J.C. Barrett, R.W. Tennant, Mammalian cell transformation : mechanisms of carcinogenesis and assays for carcinogens ,(1985)
M Takimoto, J P Quinn, A R Farina, L M Staudt, D Levens, fos/jun and octamer-binding protein interact with a common site in a negative element of the human c-myc gene. Journal of Biological Chemistry. ,vol. 264, pp. 8992- 8999 ,(1989) , 10.1016/S0021-9258(18)81892-0
Peter C. Nowell, Mechanisms of Tumor Progression Cancer Research. ,vol. 46, pp. 2203- 2207 ,(1986)
U. Hellman, C.H. Heldin, K. Miyazono, C. Wernstedt, Latent high molecular weight complex of transforming growth factor. beta. 1 J. Biol. Chem.; (United States). ,(1988)
J. M. Mitchison, The biology of the cell cycle ,(1971)
Jordan U. Gutterman, David V. Goeddel, Richard D. Williams, Axel Ullrich, Rik Derynck, Wendy H. Berger, Timothy S. Bringman, Synthesis of Messenger RNAs for Transforming Growth Factors α and β and the Epidermal Growth Factor Receptor by Human Tumors Cancer Research. ,vol. 47, pp. 707- 712 ,(1987)