Mechanisms Associated with Aging and Age-Related Disease in Drosophila
作者： Melanie Ann Jones
DOI: 10.25772/1GEC-7N27
关键词: Loss function 、 Neuroscience 、 Psychology 、 PI3K/AKT/mTOR pathway 、 Molecular genetics 、 Insulin receptor 、 Disease 、 Bioinformatics 、 Wolfram syndrome 、 Protein kinase B 、 Genetic screen
摘要: MECHANISMS ASSOCIATED WITH AGING AND AGE-RELATED DISEASE IN DROSOPHILA Melanie Ann Jones, B.S. A dissertation submitted in partial fulfillment of the requirements for degree Doctor Philosophy at Virginia Commonwealth University. University, 2010. Director: Dr. Michael Grotewiel Associate Professor, Department Human and Molecular Genetics Aging is an intrinsic process that independent obvious disease. In contrast to normal aging, age-related diseases are conditions typically manifest advanced ages, associated with explicit pathology cause disability premature death. We used Drosophila as a model investigate molecular-genetic mechanisms aging Age-related locomotor impairment (ARLI) serious condition elderly greatly impacts their quality life. Toward identifying genes influence ARLI, we performed forward genetic screen using mutants. This identified loss function mutant PDK1, component insulin signaling pathway. Additional mutants pathway PI3K Dp110, AKT also delayed ARLI. These results suggest role Wolfram Syndrome (WFS)
sci-hub.st 参考文章(263)
C Klämbt, Elisabeth Knust, Kyria Tietze, Jose A Campos‐Ortega, None, Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster. The EMBO Journal. ,vol. 8, pp. 203- 210 ,(1989) , 10.1002/J.1460-2075.1989.TB03365.X
Nadine Fresquet, Jean Médioni, Effects of ageing on visual discrimination learning in Drosophila melanogaster Quarterly Journal of Experimental Psychology Section B-comparative and Physiological Psychology. ,vol. 46, pp. 399- 412 ,(1993) , 10.1080/14640749308401079
NEIL J. NUSBAUM, Aging and sensory senescence Southern Medical Journal. ,vol. 92, pp. 267- 275 ,(1999) , 10.1097/00007611-199903000-00002
Morris Rockstein, Jaime Miquel, AGING IN INSECTS The Physiology of Insecta (Second Edition)#R##N#Volume I. pp. 371- 478 ,(1973) , 10.1016/B978-0-12-591601-1.50013-2
Isabelle PETROPOULOS, Jean MARY, Martine PERICHON, Bertrand FRIGUET, Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging. Biochemical Journal. ,vol. 355, pp. 819- 825 ,(2001) , 10.1042/BJ3550819
Éric Le Bourg, Nadège Minois, A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster. Experimental Gerontology. ,vol. 34, pp. 157- 172 ,(1999) , 10.1016/S0531-5565(98)00077-1
James F. Gusella, Marcy E. MacDonald, Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease Nature Reviews Neuroscience. ,vol. 1, pp. 109- 115 ,(2000) , 10.1038/35039051
R. McFarland, R.W. Taylor, D.M. Turnbull, Mitochondrial disease--its impact, etiology, and pathology. Current Topics in Developmental Biology. ,vol. 77, pp. 113- 155 ,(2007) , 10.1016/S0070-2153(06)77005-3
Elizabeth A. Phelan, Lynda A. Anderson, Andrea Z. Lacroix, Eric B. Larson, Older adults' views of "successful aging" how do they compare with researchers' definitions? Journal of the American Geriatrics Society. ,vol. 52, pp. 211- 216 ,(2004) , 10.1111/J.1532-5415.2004.52056.X
Raymond P. Stowe, James S. Goodwin, Effects of Aging on Immune Function Journal of Nutrition Health & Aging. ,vol. 8, pp. 9- 18 ,(2011) , 10.1007/978-1-4419-6999-6_4