Bioavailability and disposition of sodium and procaine penicillin G (benzylpenicillin) administered orally with milk to calves.

摘要: Eighteen 1-week-old Holstein calves were randomly assigned to one of three groups: (a) sodium penicillin G administered intravenously, (b) orally, or (c) procaine orally. All dosed with at 4.0 mg/kg BW. At 5 weeks age, the again. Blood samples taken serially for 24 h after both dosings. Plasma was assayed by high performance liquid chromatography (HPLC). For i.v. administration, area under concentration-time curve (AUC), 7456 and 5508 ng/mL h, systemic clearance, 0.54 0.73 L/kg significantly different (P < 0.05) 1 respectively. There no significant differences between orally within same age groups. Following oral (p.o.) there 0.01) in AUC, 760 409 terminal half-life, 2.1 1.6 time maximum concentration (TMAX), 3.0 2.3 plasma (CMAX), 85 58 ng/mL, Bioavailability 10.2 7.4% weeks,