Bacteriochlorophyll-a derivatives useful in photodynamic therapy
作者： Thomas J. Dougherty
DOI:
关键词: Alkyl 、 Chemistry 、 Photodynamic therapy 、 Metal 、 Irradiation 、 Bacteriochlorophyll A 、 Medicinal chemistry 、 In vitro 、 Stereochemistry 、 Residue (chemistry)
摘要: Compounds of formula (1) or (2), wherein M is a non-paramagnetic metal selected from Mg?+2, Sn+2?, and Zn+2, represents 2 H?+ each H+? bonded to one the N atoms connected by solid lines; R1 saturated unsaturated hydrocarbyl residue 8-25C; R2 independently group consisting vinyl, ethyl, acetyl 1-hydroxyethyl, X COOR3, R3 alkyl (1-4C); are useful in photodynamic therapy diagnosis. These compounds photosensitize target biological substrates irradiation, treating said with these sensitizers followed irradiation leads impairment destruction substrate. When administered systemically, accumulate undesired The can also be utilized vitro, for example destroy infectious cells viruses blood intended transfusion.
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