Microparticles manufactured in an oil-in-water process comprising a prostamide

作者: Patrick Hughes , Chin-Ming Chang , James Chang

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摘要: Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of anterior posterior segments eye for extended period time. The can be associated with matrix, such as matrix two polymers. Or, encapsulated by polymeric component. present oil-in-water emulsified microparticles. subconjunctivally administered used to treat or reduce at least one symptom ocular condition, glaucoma age related macular degeneration.

参考文章(250)
H Nishiwaki, Y Honda, Y Ikada, M Hashizoe, H Kimura, Y Ogura, A new vitreal drug delivery system using an implantable biodegradable polymeric device. Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 2815- 2819 ,(1994)
Daniel Montandon, Mast for sailboat ,(1986)
H. F. Edelhauser, T. W. Olsen, D. H. Geroski, Jennifer I. Lim, Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning. Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 1893- 1903 ,(1995)
G. J. Jaffe, P. A. Pearson, A. S. Berger, P. Ashton, Chen-Kuo Cheng, Intravitreal sustained-release dexamethasone device in the treatment of experimental uveitis. Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 442- 453 ,(1995)
C B Camras, K E Eakins, L Z Bito, Reduction of intraocular pressure by prostaglandins applied topically to the eyes of conscious rabbits. Investigative Ophthalmology & Visual Science. ,vol. 16, pp. 1125- 1134 ,(1977)