A new vitreal drug delivery system using an implantable biodegradable polymeric device.
作者： H Nishiwaki , Y Honda , Y Ikada , M Hashizoe , H Kimura
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摘要: PURPOSE The authors evaluated the feasibility of using an implantable biodegradable polymeric device to deliver drugs into vitreous humor. METHODS Two types devices were prepared by compression-molding polymers poly(DL-lactic acid) two different molecular weights. weights used 5,600 (device-1) and 9,100 (device-2). Sodium fluorescein (NaF) served as a hydrophilic drug marker. release dye from was studied in vitro. intravitreal kinetics NaF rabbits vivo fluorophotometry. eyes electrophysiologically histologically determine if there toxic effects. RESULTS Device-1 device-2 released for more than 25 45 days, respectively, Detectable concentrations present up 17 days 28 Both well tolerated, with no noted CONCLUSIONS These results suggested that this may be potentially effective system vitreous.
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