Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer.
作者： Tess V. Clendenen , Alan A. Arslan , Karen L. Koenig , Kerstin Enquist , Isaac Wirgin
DOI: 10.1016/J.CANLET.2007.11.002
关键词: Allele frequency 、 Oncology 、 Calcitriol receptor 、 Endocrinology 、 Linkage disequilibrium 、 Case-control study 、 FokI 、 Biology 、 Internal medicine 、 TaqI 、 Haplotype 、 Single-nucleotide polymorphism
摘要: The vitamin D receptor (VDR) is a critical mediator of the cellular effects D. associations between four common VDR polymorphisms (BSMI, APAI, TAQI, and FOKI) risk epithelial ovarian cancer (EOC) were assessed in case-control study nested within two prospective cohorts. One hundred seventy incident cases EOC 323 individually matched controls genotyped. Overall, no observed genotype analyses. Haplotypes combining three SNPs high linkage disequilibrium TAQI) also not associated with risk. These observations do support role for BSMI, FOKI predominantly Caucasian population.
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