A closer look to botulinum neurotoxin type A-induced analgesia

摘要: Chronic pain indicates a type of that lasts over time and is accompanied by diagnostic therapeutic difficulties. It follows treatment failures are common patients roam from doctor to in search an effective care program. So there urgent need for long-acting therapeutics alleviate symptoms the varied forms chronic pain. During past few years, good success has been achieved with derivative neurotoxin. shown administration this toxin can block release neurotransmitters mediators. Botulinum neurotoxin A (BoNT/A) well known as neuromuscular conditions such dystonia spasticity. However, clinical application BoNT/A continued expand. Its analgesic effect used practice satisfactory results. This review provides introduction hypothesis mechanism which eases also summarizes effects different types its potential prospects.