Regional Differences in Serotonin Transporter Occupancy by Escitalopram: An [ 11 C]DASB PK-PD Study
作者： Euitae Kim , Oliver D. Howes , Bo-Hyung Kim , Myong-Wuk Chon , Seongho Seo
DOI: 10.1007/S40262-016-0444-X
关键词: Serotonin transporter 、 Escitalopram 、 Blockade 、 PK/PD models 、 Dorsal raphe nucleus 、 Medicine 、 Pharmacology 、 DASB 、 Regional differences 、 Serotonin reuptake
摘要: Background and objective Escitalopram is one of the most commonly prescribed selective serotonin reuptake inhibitors (SSRIs). It thought to act by blocking transporter (SERT). However, its dose–SERT occupancy relationship not well known, so it clear what level SERT blockade achieved currently approved doses.
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