Tumors of Sprague-Dawley rats induced by long-term feeding of phenacetin.

摘要: Carcinogenicity of phenacetin was tested using Sprague-Dawley rats. Two groups animals containing 50 males and females per group were fed respectively with 2.5% 1.25% diet for 18 months thereafter basal 6 months. Control 65 24 Animals surviving more than regarded as effective killed. Rats that died tumor development within also animals. Every organ from the killed dead fixed in 10% formaldehyde solution examined histopathologically. Effective number rats 27 feeding group, 22 25 group. In control 19 effective. Neoplasms including spontaneous tumors detected 26 out (96.3%) 21 (77.8%) 20 (90.9%) (76.0%) 1 (5.3%) (24.0%) showed development. Histopathologically, carcinomas nasal cavity, such adenocarcinoma, squamous cell carcinoma, transitional urinary passage, renal carcinoma kidney pelvis, bladder, most conspicuous, suggesting target organs carcinogenesis. Males higher incidence compared to females. The concentration given, observed.