Effect of exposure route on potency of carcinogens.

摘要: Abstract To compare the effectiveness of different exposure routes for induction cancer in experimental animals, estimated dose associated with a 25% additional risk (RRD25) was calculated using group carcinogenic agents which both inhalation and oral ingestion bioassays were available. Comparisons made 14 rats 9 mice. Seven nine compared mice also rats. Among rats, 8 more effective via route, while 7 route The variation RRD25 values however, less than 10-fold all tested 11 An overall difference potency could not be detected statistically. In differences greater found asbestos, vinyl chloride, hydrazine. case agent form relatively insoluble particulate matter. is likely due to longer residence time particles deep lung gut, allowing degree particle dissolution an accompanying increase bioavailability. Vinyl chloride generally by at doses high enough saturate activation pathways, resulting underestimates low-dose potency. Many smaller as well those hydrazine, considered result variability design and/or quality studies. It concluded that, if conduct experiments adequate, matter are eliminated, corrections account incomplete activation, then large errors during extrapolation unlikely occur.