Comparison of contact site cancer potency across dose routes: case study with epichlorohydrin.

摘要: Risk assessment for airborne carcinogens is often limited by a lack of inhalation bioassay data. While extrapolation from oral-based cancer potency factors may be possible some agents, this not considered feasible contact site carcinogens. The change in sites (oral: g.i. tract; inhalation: respiratory tract) when switching dose routes leads to differences tissue sensitivity as well chemical delivery. This research evaluates the feasibility extrapolate across carcinogen through case study with epichlorohydrin (EPI). EPI at compared three bioassays involving different (gavage, drinking water, inhalation) use dosimetry models adjust delivery sites. Results indicate large disparity (two orders magnitude) administration expressed externally applied dose. However, peak delivered dose, and oral estimates are similar overall, within factor seven. results suggest that response more dependent upon rate than route delivery, concentration best way routes. These cannot projected other without further study.