Dual-doped thermographic phosphor particles as surrogates for green fluorescent protein-labeled cells in tests of cytometric neurocatheters

作者: S. W. Allison , G. T. Gillies

DOI: 10.1063/1.3359656

关键词: Analytical chemistryGreen fluorescent proteinPhosphorDopingChemistryLuminescenceMolecular biophysicsThermographic phosphorRadiochemistryEuropiumFluorescence

摘要: We investigated the laser-induced fluorescence of particles a compound thermographic phosphor La2O2S:Eu(1%) and Gd2O2S:Eu(1%) to see if they can serve as surrogate for cells transfected with green fluorescent protein, in tests neurocatheters used intraparenchymal cell delivery. At an excitation wavelength 337 nm concentration ≈2×106 particles ml−1, resulting slurries produced intensities at 625 that were within factor 2 those by similar number densities relevant cells, thus suggesting utility this approach.

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