Cytometric catheter for neurosurgical applications
作者： B. M. Evans , S. W. Allison , H. L. Fillmore , W. C. Broaddus , R. L. Dyer
DOI: 10.3109/03091901003639943
关键词: Cell 、 Stem cell 、 Cell therapy 、 Medicine 、 Flow cytometry 、 Port (medical) 、 Central nervous system 、 Catheter 、 Neural stem cell 、 Biomedical engineering
摘要: Implantation of neural progenitor cells into the central nervous system has attracted strong interest for treatment a variety pathologies. The replacement dopamine-producing in brain appears promising patients affected by Parkinson's disease. Previous studies cell strategies have shown that less than 10% implanted were viable 24–48 hours following implantation. We present design an instrumented cell-delivery catheter been developed to facilitate quantification delivered and determination viability. uses fibre optic probe perform fluorescence-based cytometric measurements on exiting port at tip. Results fluorescence testing data are presented show device can characterize quantity densities ranging from 60 000 600 ml−1 with coefficient 0.93 (p < 0.05, n = 6).
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