Translational medicine as a way from fundamental biomedical science to public health services
作者： O. M. Ipatova , N. V. Medvedeva , A. I. Archakov , A. I. Grigor'ev
关键词: Engineering ethics 、 Public health 、 Translational medicine 、 Alternative medicine 、 Field (Bourdieu) 、 Therapeutic monitoring 、 Treatment strategy 、 Medicine
摘要: Increasing distance between practical public health services and collecting of theoretical information in the field biomedical researches reflects necessity professional contact clinicians scientists many areas associated with medicine for active carrying over («translation») modern basic which mechanisms metabolic processes possibilities their correction are detected, to effective medical help individual patient, i.e. personified medicine. Such approach was called transmitting Examples together anamnesis morbi patient that responsible treatment strategy including doses regimens discussed.
sci-hub.st 参考文章(22)
Hua Liu, Mauricio R. Delgado, Therapeutic drug concentration monitoring using saliva samples. Focus on anticonvulsants. Clinical Pharmacokinectics. ,vol. 36, pp. 453- 470 ,(1999) , 10.2165/00003088-199936060-00006
S.A. Forbes, G. Bhamra, S. Bamford, E. Dawson, C. Kok, J. Clements, A. Menzies, J.W. Teague, P.A. Futreal, M.R. Stratton, The Catalogue of Somatic Mutations in Cancer (COSMIC). Current protocols in human genetics. ,vol. 57, ,(2008) , 10.1002/0471142905.HG1011S57
Mark Day, J. Lynn Rutkowski, Giora Z. Feuerstein, Translational Medicine—A Paradigm Shift in Modern Drug Discovery and Development: The Role of Biomarkers Pharmaceutical Biotechnology. ,vol. 655, pp. 1- 12 ,(2009) , 10.1007/978-1-4419-1132-2_1
Dongmei Zhang, Hongxia Liu, Shusheng Zhang, Xiaolan Chen, Shangfu Li, Cunlong Zhang, Xiangming Hu, Kaishun Bi, Xiaohui Chen, Yuyang Jiang, An effective method for de novo peptide sequencing based on phosphorylation strategy and mass spectrometry. Talanta. ,vol. 84, pp. 614- 622 ,(2011) , 10.1016/J.TALANTA.2010.12.035
Arantxa González, Begoña López, Javier Beaumont, Susana Ravassa, Teresa Arias, Nerea Hermida, Amaia Zudaire, Javier Díeza, Genomics and Proteomics in Heart Failure Research Revista Espanola De Cardiologia. ,vol. 62, pp. 305- 313 ,(2009) , 10.1016/S1885-5857(09)71561-0
Alexios S Strimpakos, Kostas N Syrigos, Muhammad Wasif Saif, None, The molecular targets for the diagnosis and treatment of pancreatic cancer. Gut and Liver. ,vol. 4, pp. 433- 449 ,(2010) , 10.5009/GNL.2010.4.4.433
Kathleen M. Darcy, Michael J. Birrer, Translational research in the Gynecologic Oncology Group: Evaluation of ovarian cancer markers, profiles, and novel therapies Gynecologic Oncology. ,vol. 117, pp. 429- 439 ,(2010) , 10.1016/J.YGYNO.2010.01.048
Kong M. Li, Laurent P. Rivory, Janelle Hoskins, Rohini Sharma, Stephen J. Clarke, Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients. British Journal of Clinical Pharmacology. ,vol. 63, pp. 67- 74 ,(2007) , 10.1111/J.1365-2125.2006.02710.X
Uwe Christians, Wolfgang Jacobsen, Natalie Serkova, Leslie Z. Benet, Christian Vidal, Karl-Fr. Sewing, Michael P. Manns, Gabriele I. Kirchner, Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 748, pp. 41- 53 ,(2000) , 10.1016/S0378-4347(00)00380-7
Wolfgang Egge-Jacobsen, Matthias Unger, Claus U. Niemann, Muhammad Baluom, Sumiko Hirai, Leslie Z. Benet, Uwe Christians, Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Therapeutic Drug Monitoring. ,vol. 26, pp. 546- 562 ,(2004) , 10.1097/00007691-200410000-00014