Scientific Opinion of the PPR Panel on the follow-up of the findings of the External Scientific Report ‘Literature review of epidemiological studies linking exposure to pesticides and health effects’

摘要: In 2013, EFSA published a comprehensive systematic review of epidemiological studies from 2006 to 2012 investigating the association between pesticide exposure and many health outcomes. Despite considerable amount information available, quality much this evidence was rather low limitations likely affect results so firm conclusions cannot be drawn. Studies that do not meet ‘recognised standards’ mentioned in Regulation (EU) No 1107/2009 are thus suited for risk assessment. Scientific Opinion, Panel on Plant Protection Products their residues (PPR Panel) requested assess methodological epidemiology found poor characterisation primarily defined major limitation. Frequent use case–control as opposed prospective considered another Inadequate definition or deficiencies outcomes need avoided reporting findings could improved some cases. The PPR proposed recommendations how improve reliability overcome these facilitate an appropriate recommended conduct reviews meta-analysis, where appropriate, observational useful methodology understand potential hazards pesticides, scenarios methods assessing exposure, exposure–response characterisation. Finally, approach integrate weight multiple lines evidence, including data, Biological plausibility can contribute establishing causation.