Incidence of hepatocellular carcinoma in chronic Hepatitis B and C: A prospective study of 251 patients
作者： Susumu Takano , Osamu Yokosuka , Fumio Imazeki , Masami Tagawa , Masao Omata
关键词: Gastroenterology 、 Hepatitis 、 Liver disease 、 Hepatitis C virus 、 Hepatocellular carcinoma 、 Internal medicine 、 Hepatitis C 、 Pathology 、 Cirrhosis 、 Medicine 、 Hepatitis B 、 HBsAg
摘要: The incidence of hepatocellular carcinoma (HCC) was prospectively studied in 251 chronic hepatitis patients, and compared between the 127 cases B 124 C. All patients were diagnosed by needle biopsy on entering study, consisted persistent (CPH), active (CAH)2a, CAH2b (cirrhosis not included). Of B, 5 HCC (3.9%) detected; among C cases, 13 (10.4%) detected. Thus, although mean follow-up periods same range, 2.7 times higher than (chi 2 = 3.116, P < .05). Using Kaplan-Meier method, significantly (P .0194, generalized Wilcoxon test). In C, incubation period until detected shorter when liver disease more advanced. Such a tendency observed B. occurring noncirrhotic seen only 1 case (7.7%), whereas (40%) noncirrhotic. prevalence virus (HCV) genotypes II III total followed cases.
sci-hub.se 参考文章(45)
Q. M. Tao, Y. Wang, H. Wang, W. R. Chen, Y. Sun, Q. Meng, J. Watanabe, Kusuya Nishioka, Seroepidemiology of HCV and HBV infection in northern China Gastroenterologia Japonica. ,vol. 26, pp. 156- 158 ,(1991) , 10.1007/BF02779288
Rifai Amirudin, Ham Akil, Yoshihiro Akahane, Hiroshi Suzuki, Hepatitis B and C virus infection in Ujung Pandang, Indonesia Gastroenterologia Japonica. ,vol. 26, pp. 184- 188 ,(1991) , 10.1007/BF02779295
Young Min Park, In Sik Kim, Chang Don Lee, Boo Sung Kim, Seroprevalence of antibody against hepatitis C virus (anti-HCV) in various groups of individuals in Korea Gastroenterologia Japonica. ,vol. 26, pp. 159- 163 ,(1991) , 10.1007/BF02779289
Nubia Muñoz, Allen Linsell, Epidemiology of Primary Liver Cancer Epidemiology of Cancer of the Digestive Tract. pp. 161- 195 ,(1982) , 10.1007/978-94-009-7502-6_7
Yun-Fan Liaw, Rong-Nan Chien, I-Shyan Sheen, Deng-Yn Lin, Hsien-Hong Lin, Chia-Ming Chu, Hepatitis C virus infection in patients with chronic liver diseases in an endemic area for hepatitis B virus infection Gastroenterologia Japonica. ,vol. 26, pp. 167- 169 ,(1991) , 10.1007/BF02779291
W Szmuness, Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progres en virologie medicale. ,vol. 24, pp. 40- 69 ,(1978)
Epidemiology of cancer of the digestive tract M. Nijhoff , Distributors for the U.S. and Canada, Kluwer Boston. ,(1982) , 10.1007/978-94-009-7502-6
Stephenie P. Joyner, SUGI supplemental library user's guide SAS Institute. ,(1983)
Isaburo Fujimoto, Yoshinori Urano, Aya Hanai, Kunio Okuda, Changing incidence of hepatocellular carcinoma in Japan. Cancer Research. ,vol. 47, pp. 4967- 4972 ,(1987)
S Takada, Y Gotoh, S Hayashi, M Yoshida, K Koike, Structural rearrangement of integrated hepatitis B virus DNA as well as cellular flanking DNA is present in chronically infected hepatic tissues. Journal of Virology. ,vol. 64, pp. 822- 828 ,(1990) , 10.1128/JVI.64.2.822-828.1990