Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
作者： B. Pulendran , J. L. Smith , G. Caspary , K. Brasel , D. Pettit
关键词: Interleukin 、 Immune system 、 Immunology 、 Acquired immune system 、 Cytokine 、 Isotype 、 Dendritic cell 、 Adoptive cell transfer 、 Granulocyte macrophage colony-stimulating factor 、 Biology
摘要: Dendritic cells (DCs) are unique in their ability to stimulate T and initiate adaptive immunity. Injection of mice with the cytokine Flt3-ligand (FL) dramatically expands mature lymphoid myeloid-related DC subsets. In contrast, injection a polyethylene glycol-modified form granulocyte/macrophage colony-stimulating factor (GM-CSF) into only subset. These subsets differ profiles they induce vivo. The lymphoid-related subset induces high levels Th1 cytokines interferon γ interleukin (IL)-2 but little or no Th2 cytokines. large amounts IL-4 IL-10, addition IL-2. FL- GM-CSF-treated injected soluble ovalbumin display dramatic increases antigen-specific antibody titers, isotype seem critically dependent on used. Although FL treatment up 10,000-fold increase ovalbumin-specific IgG2a more modest IgG1 GM-CSF favors predominantly response levels. data suggest that distinct have strikingly different influences type immune generated vivo may thus be targets for pharmacological intervention.
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