Premature mortality in refractory partial epilepsy: does surgical treatment make a difference?

摘要: Background Epilepsy carries an increased risk of premature death. For some people with intractable focal epilepsy, surgery offers hope for a seizure-free life. The authors aimed to see whether epilepsy influenced mortality in epilepsy. Methods audited survival status two cohorts (those who had and those presurgical assessment but did not have surgery). Results There were 40 known deaths the non-surgical group (3365 person years follow-up) 19 surgical (3905 person-years follow-up). Non-operated patients 2.4 times (95% CI 1.4 4.2) as likely die surgery. They 4.5 1.9 10.9) probable epilepsy-related In group, ongoing seizures 1 year after 4.0 1.2 13.7) or only simple partial seizures. Time-dependent Cox analysis showed that yearly outcome significantly affect (HR 1.3, 95% 0.9 1.8). Conclusion Successful was associated reduced mortality, compared refractory treatment. To extent, is be conferred by inducing freedom from It certain better attributable surgery, treatment decisions randomised, there may inherent differences between groups.