Studying cyto and myeloarchitecture of the human cortex at ultra-high field with quantitative imaging: R1, R2* and magnetic susceptibility

摘要: Abstract In this manuscript, the use of quantitative imaging at ultra-high field is evaluated as a mean to study cyto and myelo-architecture cortex. The contrasts used are longitudinal relaxation rate (R1), apparent transverse (R2*) susceptibility mapping (QSM). were computed using high resolution in-vivo (0.65mm isotropic) brain data acquired 7 T. performance different approaches was by visualizing contrast between known highly myelinated primary sensory cortex regions neighbouring transition from inner layers outer (from white matter pial surface) human cortex, which have varying cyto- myelo architecture, evaluated. across through depth behaviour observed for maps in good agreement subjects, clearly allowing differentiation Brodmann regions, suggesting these features could be individual cortical parcellation. While both R1 R2* decrease monotonically surface due myelin iron magnetic more complex reflecting its opposing sensitivity concentration.