Multivariate combination of magnetization transfer, T 2 * and B0 orientation to study the myelo-architecture of the in vivo human cortex

摘要: Abstract Recently, T2* imaging at 7 Tesla (T) MRI was shown to reveal microstructural features of the cortical myeloarchitecture thanks an increase in contrast-to-noise ratio. However, several confounds hamper specificity measures (iron content, blood vessels, tissues orientation). Another metric, magnetization transfer ratio (MTR), is known also be sensitive myelin content and thus would excellent complementary measure because its underlying contrast mechanisms are different than that from T2*. The goal this study combine MTR using multivariate statistics order gain insights into content. Seven healthy subjects were scanned 7 T 3 T obtain data, respectively. A estimation model (MMEM) developed, consists (i) normalizing values (ii) extracting their shared information independent component analysis (ICA). B0 orientation dependence thickness computed included model. Results showed high correlation between whole cortex (r = 0.76, p  This demonstrates highly correlated cortex. combination MTR, T2*, CT may a useful means with more any individual methods. MMEM framework extendable other contrasts such as T1 diffusion MRI.