Vitamin D receptor polymorphism FokI and cancer risk: a comprehensive meta-analysis.

摘要: Numerous studies investigated the associations of VDR polymorphisms with various types cancer, suggesting an influence on cancer risk. FokI is one most frequently analysed but results from single are contradictory. We performed a meta-analysis looking at association between and all sites investigating sources heterogeneity. identified 77 independent up to April 2014. presented summary odds ratios (SORs) by sites, ethnicity study features. found significant ovarian for ff genotype versus FF no heterogeneity: SOR = 1.20 (95% CI: 1.02-1.41, I (2) 0%). Moreover, we increased risk any cancer: 1.08 1.01-1.16, 58%). A confirmed among Caucasian, in Hardy-Weinberg equilibrium nested case-control studies. Furthermore, equilibrium, skin was significantly associated FokI: 1.24 1.01-1.54; 24%) FF. The estimated number cases attributable 4221 52858 worldwide each year. No indication publication bias site. In conclusion, overall polymorphism differential effect ethnicity. particular, estimates indicate increase However, other factors may act modifying association, further needed clarify impact