Views of immunology: effector T cells

作者: Deborah A. Lewinsohn , Marielle C. Gold , David M. Lewinsohn

DOI: 10.1111/J.1600-065X.2010.00997.X

关键词: ImmunologyIntracellular parasiteAntigen processingT lymphocyteBiologyAntigen presentationEffectorNatural killer T cellAntigenImmune systemImmunology and Allergy

摘要: For many intracellular bacteria, both adaptively acquired and innately encoded effector T cells play a central role in the control, some cases, clearance of these pathogens. Through rapid identification those harboring have capacity to directly control infection shape immune response pathogen. Here, we review mechanisms by which emphasize means they recognize their targets. As will become evident, diversity redundant non-redundant conjunction with broad recognition protein non-protein antigens allows for array bacterial pathogens lessens likelihood evasion.

参考文章(160)
Mark K. Slifka, Fernando Rodriguez, J. Lindsay Whitton, Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells Nature. ,vol. 401, pp. 76- 79 ,(1999) , 10.1038/43454
Arno Müllbacher, Ron Tha Hla, Crisan Museteanu, Markus M. Simon, Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice Journal of Virology. ,vol. 73, pp. 1665- 1667 ,(1999) , 10.1128/JVI.73.2.1665-1667.1999
Michael Walch, Elisabeth Eppler, Claudia Dumrese, Hanna Barman, Peter Groscurth, Urs Ziegler, Uptake of Granulysin via Lipid Rafts Leads to Lysis of Intracellular Listeria innocua Journal of Immunology. ,vol. 174, pp. 4220- 4227 ,(2005) , 10.4049/JIMMUNOL.174.7.4220
Douglas W. White, Vladimir P. Badovinac, George Kollias, John T. Harty, Cutting edge: antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice. Journal of Immunology. ,vol. 165, pp. 5- 9 ,(2000) , 10.4049/JIMMUNOL.165.1.5
Noah S. Butler, Nathan W. Schmidt, John T. Harty, Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites. Journal of Immunology. ,vol. 184, pp. 2528- 2538 ,(2010) , 10.4049/JIMMUNOL.0903529
Ulrich E. Schaible, Helen L. Collins, Stefan H.E. Kaufmann, Confrontation between Intracellular Bacteria and the Immune System Advances in Immunology. ,vol. 71, pp. 267- 377 ,(1999) , 10.1016/S0065-2776(08)60405-8
Patricia Wilhelm, Uwe Ritter, Stefanie Labbow, Norbert Donhauser, Martin Röllinghoff, Christian Bogdan, Heinrich Körner, Rapidly fatal leishmaniasis in resistant C57BL/6 mice lacking TNF. Journal of Immunology. ,vol. 166, pp. 4012- 4019 ,(2001) , 10.4049/JIMMUNOL.166.6.4012
Vojo Deretic, Monica Delgado, Isabelle Vergne, Sharon Master, Sergio De Haro, Marisa Ponpuak, Sudha Singh, Autophagy in Immunity Against Mycobacterium tuberculosis: a Model System to Dissect Immunological Roles of Autophagy Current Topics in Microbiology and Immunology. ,vol. 335, pp. 169- 188 ,(2009) , 10.1007/978-3-642-00302-8_8
Jamie R. Schoenborn, Christopher B. Wilson, Regulation of interferon-gamma during innate and adaptive immune responses. Advances in Immunology. ,vol. 96, pp. 41- 101 ,(2007) , 10.1016/S0065-2776(07)96002-2