作者: Douglas W. White , Vladimir P. Badovinac , George Kollias , John T. Harty
关键词: Interleukin 21 、 Tumor necrosis factor alpha 、 Cytolysis 、 Immunology 、 Molecular biology 、 CD8 、 Cytotoxic T cell 、 Perforin 、 Biology 、 Immunity 、 Spleen
摘要: The mechanisms by which CD8+ T cells mediate immunity against bacterial pathogens remain largely unknown. Perforin-dependent cytolysis plays a role, but is not required for cell-mediated Listeria monocytogenes. TNF essential cell to L. monocytogenes, the cellular source of undefined. TNF-deficient and TNF/perforin double-deficient mice were used generate specific an monocytogenes-derived Ag. Wild-type mediated antilisterial in wild-type host mice, revealing that cell-derived immunity, demonstrating role derived from other types. liver, spleen, recipient suggesting perforin-independent spleen requires TNF.