ERK plays the baddie (again).

作者: Paul Dent

DOI: 10.4161/CBT.26377

关键词: MAPK/ERK pathwayApoptosisAdenocarcinomaMitogen-Activated Protein Kinase 3Cell biologyAutocrine signallingBiologyCancerStimulationCamptothecin

摘要: It has been known for many years that elevated signaling by the ERK1/2 pathway is frequently associated with the growth and survival of many tumor cell types under a variety of normal …

参考文章(9)
Raghavendra S. Patwardhan, Rahul Checker, Deepak Sharma, Santosh K. Sandur, Krishna B. Sainis, Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normal and Tumor Cells PLoS ONE. ,vol. 8, pp. e65929- ,(2013) , 10.1371/JOURNAL.PONE.0065929
M. Danielle Bareford, Hossein A. Hamed, Jeremy Allegood, Nichola Cruickshanks, Andrew Poklepovic, Margaret A. Park, Besim Ogretmen, Sarah Spiegel, Steven Grant, Paul Dent, Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling Cancer Biology & Therapy. ,vol. 13, pp. 793- 803 ,(2012) , 10.4161/CBT.20562
Michal Hetman, Kevin Kanning, Jane E. Cavanaugh, Zhengui Xia, Neuroprotection by Brain-derived Neurotrophic Factor Is Mediated by Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase * Journal of Biological Chemistry. ,vol. 274, pp. 22569- 22580 ,(1999) , 10.1074/JBC.274.32.22569
Minyoung Lee, Sun Young Kim, JongGuk Kim, Hak-Su Kim, Sang-Man Kim, Eun Ju Kim, Mitogen-activated protein kinase phosphatase-1 inhibition and sustained extracellular signal-regulated kinase 1/2 activation in camptothecin-induced human colon cancer cell death. Cancer Biology & Therapy. ,vol. 14, pp. 1007- 1015 ,(2013) , 10.4161/CBT.26044
Gangadharan B. Sajithlal, Hossein A. Hamed, Nichola Cruickshanks, Laurence Booth, Seyedmehrad Tavallai, Jahangir Syed, Steven Grant, Andrew Poklepovic, Paul Dent, Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells. Molecular Pharmacology. ,vol. 84, pp. 562- 571 ,(2013) , 10.1124/MOL.113.088005
Kristoffer Valerie, Adly Yacoub, Michael P. Hagan, David T. Curiel, Paul B. Fisher, Steven Grant, Paul Dent, Radiation-induced cell signaling: inside-out and outside-in Molecular Cancer Therapeutics. ,vol. 6, pp. 789- 801 ,(2007) , 10.1158/1535-7163.MCT-06-0596
C. Andreadi, L.-K. Cheung, S. Giblett, B. Patel, H. Jin, K. Mercer, T. Kamata, P. Lee, A. Williams, M. McMahon, R. Marais, C. Pritchard, The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes & Development. ,vol. 26, pp. 1945- 1958 ,(2012) , 10.1101/GAD.193458.112