Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction
作者： Zakia Sultana , Kaushik Maiti , Lee Dedman , Roger Smith
DOI: 10.1016/J.AJOG.2017.11.567
关键词: Senescence 、 Senescence-associated beta-galactosidase 、 Physiology 、 Preeclampsia 、 Senescence-associated heterochromatin focus 、 Medicine 、 Pregnancy 、 Small for gestational age 、 Telomere 、 Placenta
摘要: The placenta ages as pregnancy advances, yet its continued function is required for a successful outcome. Placental aging physiological phenomenon; however, there are some placentas that show signs of earlier than others. Premature placental senescence and implicated in number adverse outcomes, including fetal growth restriction, preeclampsia, spontaneous preterm birth, intrauterine death. Here we discuss cellular senescence, state terminal proliferation arrest, how regulated. We also explore the role aberrant alters function, contributing to pathophysiology labor/birth, unexplained
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