Human catalase gene polymorphism (CAT C‐262T) and risk of male infertility

摘要: Summary Infertility is the failure of a couple to engender after endeavouring at least one full year unprotected intercourse. It has been reported that reactive oxygen species contributed pathogenesis various disease. To inactivate ROS cells biosynthesise several antioxidant enzymes, them catalase which contributes H2O2 H2O and O2. This study set out delineate association C-262T polymorphism with idiopathic male infertility. The included 195 men infertility 190 healthy volunteers. Genomic DNA was extracted from peripheral blood leucocytes. Genotype allele frequencies were determined in patients controls using allele-specific PCR (AS-PCR). prevalence genotype CAT CC/CT/TT 31.79%, 65.12% 3.07%, respectively, infertile subjects, as against 24.73%, 55.26% 20%, Statistical analysis emerged significant difference comparison either (P < 0.05). Taking into accounts results, indicates CAT-262T/T confers less susceptibility Further studies larger numbers are required for further evaluation confirmation our finding.