Polymorphisms in Oxidative Stress–Related Genes Are Not Associated with Prostate Cancer Risk in Heavy Smokers

摘要: Oxidative stress, associated with aging and inflammation, is likely to play a role in the etiology of prostate cancer. We evaluated potential associations between gene variants that result reduced neutralization reactive oxygen species (ROS; MnSOD Ala-16Val, CAT -262 C>T, GPX1 Pro200Leu) cancer risk among 724 men incident who participated Carotene Retinol Efficacy Trial (CARET) cohort, randomized trial for prevention lung history smoking and/or asbestos exposure. Odds ratios (OR) 95% confidence intervals (95% CI) were estimated by logistic regression. Nested case-control analyses included study participants available DNA (n = 533 cases 1,470 controls), matched race, age, length follow-time. Overall, there no genotypes MnSOD, CAT, risk, although diagnosed before age 65, TT genotype was increased (OR, 2.0; CI, 0.97-3.95). Further stratified factors related environmental oxidative stress exposures did not modify associations. When calculating number alleles hypothetically protection against ROS, nonsignificant relationship carriage five or more alleles, comparison less than 0.90-4.42). In conclusion, it does seem have an influence on this cohort smokers exposed asbestos, possible cumulative defects from may disease.