Primates: Their use in research on vasectomy

摘要: Studies based on experimental vasectomies clearly reveal marked species differences in response to vasectomy. In rats, vasectomy invariably results granuloma formation at the surgical site. rabbits, immune-complex orchitis develops. Allergic may also develop guinea pigs, and morphological lesions can be adoptively transferred. My co-workers I have been able study systematically, biochemically, hormonally, pathologically, immunologically, primates vasectomized up 14 years earlier compare them with age-matched controls. We monitored antibody levels rhesus cynomolgus macaques by sperm-agglutination, sperm-immobilization, indirect immunofluorescence techniques. Antibodies almost every monkey, some as early 10 days after About 50% retain such circulating antisperm antibodies. men, development is less rapid, about half of men detectable levels. Testicular histopathological studies revealed orchitis, aspermatogenesis, or both, resembling allergic most monkeys one-fourth Limited human material testicular changes. Epididymitis epididymal occur exclusively animals. Use has significantly more granular deposits IgA, IgG, and/or C3 basal lamina ductus efferens caput epididymidis monkeys. Similar not done. Both proved excellent models for research atherosclerosis so used determine whether constant sperm antigen leakage causes that might result arteritis atherosclerosis. Evaluation cardiovascular systems from animals frequent, extensive, severe arteriosclerosis than Epidemiological are currently under way an effect occurs