Rhodopsin phosphorylation in developing normal and degenerative mouse retinas.
作者： T A Shuster , D B Farber
DOI:
关键词: Phosphatase 、 Cell biology 、 Heterozygote advantage 、 G protein 、 Rhodopsin kinase 、 Biology 、 Phosphorylation 、 Retina 、 Rhodopsin 、 Lesion 、 Internal medicine 、 Endocrinology
摘要: The developmental pattern of rhodopsin phosphorylation in degenerative (rdle homozygote) and normal (rd/+ heterozygote) mouse retina has been investigated. results indicate that levels are comparable the 2 retinas up to about 10 days age but is not. substantially reduced during development. This abnormality may be an expression rd lesion. kinase/phosphatase system, G protein, visual pigment all involved modulation cGMP-phosphodiesterase activity retinas. A defect any these components could account for level retinas, resulting cGMP accumulation subsequent photoreceptor degeneration.
arvojournals.org参考文章(4)
A Sitaramayya, P A Liebman, Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches. Journal of Biological Chemistry. ,vol. 258, pp. 12106- 12109 ,(1983) , 10.1016/S0021-9258(17)44137-8
D B Farber, R N Lolley, Enzymic basis for cyclic GMP accumulation in degenerative photoreceptor cells of mouse retina. Journal of cyclic nucleotide research. ,vol. 2, pp. 139- 148 ,(1976)
D. B. Farber, R. N. Lolley, Cyclic guanosine monophosphate. Elevation in degenerating photoreceptor cells of the c3h mouse retina. Science. ,vol. 186, pp. 449- 451 ,(1974) , 10.1126/SCIENCE.186.4162.449
P.J.G.M. van Breugel, F.J.M. Daemen, S.L. Bonting, Biochemical aspects of the visual process. XXXIII. A convenient purification procedure of rhodopsin by means of affinity chromatography Experimental Eye Research. ,vol. 24, pp. 581- 585 ,(1977) , 10.1016/0014-4835(77)90115-4